MyAza (Azacitidine for Injection) contains Azacitidine IP, which is a pyrimidine The finished product is supplied in a sterile form for reconstitution as a. No formal clinical drug interaction studies with azacitidine have been conducted. The printed package leaflet of the medicinal product must state the name. Drug: Azacitidine – Vidaza® Oncology – Intravenous Dilution Data. (, ) – [ SEE PACKAGE INSERT FOR ADDITIONAL DETAILS]].
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Additionally, male patients with a female partner of reproductive potential should use effective contraception during and for 3 months after azacitidine therapy due to the risk of male-mediated teratogenicity.
Azacitidine (Vidaza) | – A Hematology Oncology Wiki
Controlling Occupational Exposure to Hazardous Drugs. Azacitidine is available as a single-use, mg lyophilized powder vial. Vigorously shake or roll the vial until all solids are dissolved.
Counsel patients about the reproductive risk and contraception requirements during azacitidine treatment. Whether azacitidine metabolism may be affected by known microsomal enzyme inhibitors or inducers has not been studied. Rotate sites for each injection thigh, abdomen, or upper arm. Bone marrow suppression including anemia, neutropenia, and thrombocytopenia has been commonly reported. Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit.
Rotate sites for each injection thigh, abdomen, or upper arm. Azacitidine induces cytotoxicity in rapidly dividing cells that are no longer responsive to normal cell growth control mechanisms. Treatment may be continued as long as the patient continues to benefit. Non-proliferating cells are relatively insensitive to azacitidine.
Azacitidine – Drug Information – Chemocare
Inzert time to leukemic transformation was 21 months in the azacitidine arm compared with 13 months in the supportive care arm. However, you should always inform your health care provider if you experience any unusual symptoms. Your email has been sent. Advise pregnant women of the potential risk to the fetus.
Azacitidine’s anticancer effects are believed to be twofold.
It is recommended that patients be treated for a minimum of 4 to 6 treatment cycles. Reconstitute each vial with 10 mL sterile water for injection. Packgae dosage adjustment in subsequent cycles may be required based on nadir counts and hematologic response.
Special Populations The effects of renal or hepatic impairment, gender, age, azaciyidine race on the pharmacokinetics of azacitidine have not been studied [see Dosage and Administration 2.
If it comes in contact with mucous membranes, flush thoroughly with water. For more detail, see “How this drug works” section below. Administer the azacitidine admixture IV over 10 to 40 minutes; complete the infusion within 1 hour of azacitidine vial reconstitution.
Azacitidine is administered as a subcutaneous injection or as an intravenous IV infusion. Drug-Drug Interactions Drug interaction studies with azacitidine have not been conducted. Azacitidine has been designated an orphan drug for this indication. When there is an increase in DNA methylation this can result in the blockage of the activity of “suppressor genes” that regulate cell division and growth.
The potential of azacitidine to inhibit cytochrome P CYP enzymes is not known. Dilute immediately by injecting the calculated amount of azacitidine inseert a 50 to mL infusion bag of either 0. Give new injections at least one inch from an old site; do not inject in a site that is tender, bruised, red, or hard. Recipient’s Email Separate multiple email address with a comma Please enter valid email address Recipient’s email is required.
Quality of life QOL was also assessed in this study.
The reconstituted product may be kept in the vial or drawn into azaxitidine syringe. To re-suspend, pwckage roll the syringe between the palms until a uniform, cloudy suspension is achieved. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function [see Warnings and Precautions 5.
We strongly encourage you to talk with your health care professional about your specific medical condition and treatments.
Azacitidine is an anti-cancer “antineoplastic” or “cytotoxic” chemotherapy drug. Bone marrow suppression, neutropenia, thrombocytopenia. Clinical trials have not demonstrated appreciable response in children with relapsed AML treated with azacitidine.